P.N. SahayPrem Chand Sao2024-07-122024-07-122000https://krishikosh.egranth.ac.in/handle/1/5810211858.Xylazine @ 0.10 mg/kg, Ketamine @ 8 mg/kg and their combination @ 0.05 mg/kg + 6 mg/kg produced moderate analgesia and satisfactory sedation permitting surgery of short duration. (2) The combination @0.10 mg/kg + 8 mg/kg of Xylazine and Ketamine respectively, induced excellent analgesia, deep. sedation and optimum muscle relaxation for a longer period facilitating surgery of varying magnitude and longer duration in the posterior thoracic region. (3) The other five dose schedules (0.02 mg/kg, 0.05 mg/kg of Xylazine, 4 mg/kg, 6 mg/kg of Ketmine and 0.02 mg/kg + 4 mg/kg of combination were not found satisfactory due to one or the other shortcomings, viz., lack of sedation, very mild analgesia, inadequate muscle relaxation etc. (4) Dose dependent hyperglycaemia was a consistent feature following epidural administration of the anaesthetic agents. alone or in combination. This was transient in nature as there was evidence of normalisation by 24 hours.EnglishThesis