Agrawal, D.K.Singh, Atul Kumar2019-06-222019-06-222005-06http://krishikosh.egranth.ac.in/handle/1/5810109571The present investigation was carried out to study the prolonged, toxic effect of endosulfan and chlorpyriphos in poultry using “No Observable Adverse Effect Level”. Hundred 2-week-old chicks (divided into 3 groups) were used for a period of 2 months. The birds of group I given normal basal ration served as control. Group II birds were fed endosulfan (30 ppm) while group III birds were given chlorpyriphos (0.3 ppm) treated feed. Five birds from each group were taken after every 10 days interval for collection of blood and serum samples. Tissue samples from liver, spleen, thymus and bursa of Fabricius were collected for Histopathological examination after conducting the post mortem. In addition, liver, kidney and muscles were taken to study the level of pesticide residues in these organs. In the present investigation, no significant change in Hb and PCV occurred in any group. Leucopenia and lymphopenia recorded in present study. A decrease in total serum protein and albumin content in the pesticides treated birds due to hepatic dysfunction. Histopathological examination of organs collected showed mild to severe damage with increase in duration. From the present study, it may be concluded that even NOAEL dose of endosulfan and chlorpyriphos can cause hemato-biochemical and pathomorphological changes, which may be responsible for immune competence, vaccinal failure and mortality among birds.ennullThesis