Khera, K.S.Sukhmanpreet Kaur2017-06-152017-06-152016http://krishikosh.egranth.ac.in/handle/1/5810020429The present study was conducted to investigate the toxic effects of profenofos on female albino rats at two subchronic doses of 1/10th and 1/50th of LD50 (430.89 mg/kg b.w.) for six weeks. Commercial formulation of profenofos (Curacron 50 EC) was used for treatment. Hyperactivity was observed in rats treated with 1/10th of LD50 of profenofos. Relative weight of reproductive organs was found to be significantly decreased in treated rats. Feed intake and estrous cyclicity was found to be significant during treatment. Biochemical parameters like total proteins, lipids, phospholipids, cholesterol and phosphatases decreased significantly in ovaries of treated rats as compared to the control rats. Antioxidant activity, concentration of antioxidative enzymes and lipid peroxidation showed alterations in treated rats. Microsomal degranulation increased at dose dependent manner which indicated that profenofos has a potential for carcinogenicity. Increase in the frequencies of micronucleated polychromatic erythrocytes emphasised the genotoxic effect of profenofos in bone marrow cells of treated rats. Levels of estrogen and luteinising hormone increased while progesterone and follicle stimulating hormone decreased significantly in plasma of treated rats. Follicular atresia also increased in ovaries of treated rats. Histological examination of female reproductive organs in treated rats also showed significant alterations. Profenofos intoxication through hormones has resulted in biochemical and histopathological changes in reproductive parameters in treated female rats.ennullThesis