Dr. D. J. GhodasaraVIHOL PRITI DILIPSINH2017-07-252017-07-252008http://krishikosh.egranth.ac.in/handle/1/5810026158The present research work was conducted on 30 male and 30 female wistar rats to study the toxicopathological and genotoxic effects of repeated dose (28 days) of sodium dichromate. Wistar rats were randomly divided into 6 different groups with five males and five females in each group. Animals of group I to IV were given 0.625mg/kg b.wt, 1.25 mg/kg b.wt, 2.5 mg/kg b.wt, 5 mg/kg b.wt sodium dichromate by gavage for 28 days whereas group V and group VI were administrated only water as negative (vehicle) control and cyclophosphamide as positive control respectively. After completion of 28 days treatment, blood samples were collected for haematology and serum biochemical analysis from retro-orbital plexus with the help of capillary tube. The animals were sacrificed by cervical dislocation and bone marrow was collected for genotoxicity study. Necropsy examination was performed in all sacrificed animals and gross lesions were recorded. Tissue samples (lung, liver, kidney, spleen, intestine, testes, brain and stomach) were collected in 10% formalin solution for histopathological examination. ienVeterinary PathologyStudyThesis