Parsania, R. R.Kelawala, Nareshkumar H.2018-06-142018-06-141989http://krishikosh.egranth.ac.in/handle/1/5810052935A study on general anaesthesia using ketamine, propofol and propofol-ketanine as anaesthetic and pre-anaesthetic medication with diazepam was conducted in 12 healthy adult female goats, divided into three groups of four animal each. Induction of anaesthesia in all the groups was smooth without any major complications, however, it was significantly faster in the groups where propofol was used as an anaesthetic agent. Duration of anaesthesia was significantly longer in the group where propofol was followed by ketamine anaesthesia. Mean sitting time, standing time and complete recovery time were significantly longer with ketamine and propofol-ketamine groups than with propofol group. Recovery was smooth and quick without any major complications. There was significant increase in heart rate, respiratory rate and decrease in body temperature in the animals where ketamine was used as a single anaesthetic agent, whereas, they were insignificant in the animals where propofol was used as an anaesthetic agent. However, heart rate and respiratory rate were significantly increased and insignificant change in body temperature were recorded in the animals using propofol-ketamine combination. Haematological study during and after anaesthesia revealed non-significant reduction in TEC, TLC and Hb concentration and significant decrease in PCV in all the groups. Biochemical studies during and after anaesthesia revealed - significant increase in blood glucose in all the groups, whereas, non-significant increase in BUN, enzymes - SGOT, SGPT, AKP, and ACP and electrolytes - Na+, K+ and Cl- in all the groups. Serum creatinine was significantly increased in the animals where propofol was used as an Induction as well as maintenance agent, whereas, Increase was non-significant in other animals. The present study indicated that the use of propofol is a safe alternate anaesthetic procedure to the conventional ketamine or barbiturate anaesthesia.enVETERINARY SURGERY AND RADIOLOGYA STUDYThesis