YADAVA, K.P.DUTTA, RANJIT KUMAR2023-04-102023-04-101988https://krishikosh.egranth.ac.in/handle/1/5810196221EFFECT OF PYROGEN INDUCED FEVER ON BIOKINETICS OF DULFADIMIDINE AND ITS INTERACTION WITH SALICYLATE IN GOATS1.'Goat fever model was constructed with two successive LPS endotoxin injections given at zero and 5 hr which maintained fever above 0.83°c upto 12 hr. 2. It was observed that the mean CPmax and CPmin of free SDD following i.v. administration were higher and the duration of CP ther was longer in febrile (SDD-F) than the corresponding values observed for normal (SDD-N) group as reflected in 30.14% increase in the plasma half life which suggested increased ionization of the drug at lowered plasma pH and consequent 'ion trapping' in febrile goats. 3. An overall higher mean plasma concentration of SDD in (SDD+SSA-N) group with 20.66% increase in plasma half life as compared to that in (SDD-N) group correlated well with the slower rate and extent of SDD biotransformation due to its interaction with SSA. 4. Evidence was adduced that the overall sojourn and the CP ther of SDD were longer with 29.41% increase in the plasma half life in febrile (SDD-F) as compared to that in (SDD+SSA-F) group following i.v. dose which indicated plasma protein binding competition with SDD and subsequent elimination of SDD in the febrile interaction group. 5. It was observed that mean CPmax and Cpuin were found to be higher in (SDD+SSA-F) as compared to that in (SDD+SSA-N) group following concomitant i.v. SDD+SSA administration;EnglishThesis