Kandasamy, ThangavelVembuvizhivendan, TamilamKannanTANUVAS2020-07-072020-07-072018-07http://krishikosh.egranth.ac.in/handle/1/5810148789TNV_SIJVS_2018_6(1)1-4The emergence and diffusion of antibiotic-resistant bacteria has been a major public health problem for many years now. In this study, antibiotic resistance of Escherichia coli was investigated. The occurrence of colibacillosis was 65% in poultry. This study also revealed that the E. coli (78) isolates were more susceptible to levofloxacin (92.3%), enrofloxacin (88.4), ofloxacin (83.3%), gentamicin (73%), ceftriaxone (60.3) and neomycin (54%). Rationale use of these drugs may prevent the development of resistant isolates of E. coli in future. The E. coli isolates were resistant to amoxicillin (74.6%), cloxacillin (70.6%), tetracycline (60%) and amikacin (50%). Indiscriminate use, improper selection, improper dose, incorrect duration of antibiotics at farm level may be responsible for such a higher occurrence of resistance.enVeterinary ScienceArticle