Thaker, A. M.Siddiqui, M. Amir.2018-05-222018-05-222004http://krishikosh.egranth.ac.in/handle/1/5810047172The present study was conducted in 8 to 10 week old WLH cockerels, which were vaccinated with Fl vaccine of ranikhet disease at day old age. Approximate lethal medium dose (ALD50) of quinalphos (diethyl, 2-quinoxalyIphosphorothionate) and imidacloprid (1-{(6-chloro-3-pyridinylmethyl}-N-nitro-2-imadazolidinimine) was found to be 2.5 mg and 50 mg per kg body weight, respectively. l/50th and l/25th of ALD50 of both the insecticide were selected. In different groups of birds, daily oral administration of 50 and 100 ug per kg body weight of quinalphos and 1 and 2 mg per kg body weight of imidacloprid, suspended in 1 ml of groundnut oil, was carried out for 28 days. Before the start of administration of either insecticide or groundnut oil (control group) all the birds were vaccinated with Newcastle Disease Vaccine (R2B). All the birds were monitored for any observable toxic symptoms throughout the experimental period and they were also weighed weekly to monitor body weight gain. The blood samples were collected from wing vein at weekly interval and were analyzed for hematological, biochemical and immunological parameters. No observable symptoms were noticed throughout the investigation period. In first week of treatment, there was no significant change in the mean body weight of quinalphos and imidacloprid treated birds as compared to control. However, in the subsequent week there was a reduction in the body weight of both the insecticides treated birds. Both the insecticides produced hyperglycemia but did not affect total plasma cholesterol, packed cell volume and hemoglobin level. Initially after 7 days of treatment, plasma acetylcholenestrase were significantly decreased in quinalphos treated birds and was remained decreased until the end of experiment. Imidacloprid did not show any sign of acetylcholenestrase inhibition. Plasma transaminases viz. serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) were increased in all the insecticide treated groups which was significant after 14 days of treatment. Total protein was decreased in all the insecticide treated birds after 14 days of treatment where as total globulin was decreased only in quinalphos treated groups. Antibody titre against NDV vaccine was significantly decreased in both of the insecticide treated group at first week of treatment, but beyond 14 days of treatment, antibody titre level did not show any significant reduction.enVETERINARY PHARMACOLOGY AND TOXICOLOGYA STUDYThesis