Raveendran, SPrahlad, SapkotaKAU2021-01-082021-01-081985170127https://krishikosh.egranth.ac.in/handle/1/5810159577MVScA study on intravenous regional anaesthesia (IVRA) of the hind – limbs was conducted in 18 bucks, weighing 15 to 25 kg body – weight (in four groups). Lignocaine hydrochloride 2% colution was used as the anaesthetic. Four dose levels viz., 4 – 5 mg; 5 - 6 mg; 6 – 7 mg and 7 – 9 mg/kg body – weight were employed. A tourniquet was applied around the limb above the stifle joint. After a 10 min period of pre – injection tourniquet ischaemic, the anaesthetic was administered through saphenous vein following exsanguination. Anaesthetic effect was ascertained by pin – pricking and pinching the interdigital space. In nine animals the effect of IVRA on wound healing was studies. The onset and duration of anaesthesia and the time for waning away of anaesthesia were also recorded. Onset of anaesthesia was noticed in 2.50 + 0.84; 2.0 + 0.82; 2.86 + 1.34 and 2.43 + 1.40 min. Duration of anaesthesia in the four groups was 25.0 + 7.77; 24.86 + 3.80 ; 21.43 + 6.08 and 30.71 + 4.92 min respectively including a short duration after the release of tourniquet. The complete disappearance of anaesthetic effect was noticed by 6.17 + 4.54; 4.28 + 1.38 ; 5.43 + 2.07 and 3.86 + 1.21 min after the release of tourniquet. The anaesthetic effects were first apparent at the phalangeal region and progressed gradually upwards to the level of tourniquet and waned away in the reverse order. The healing of wound was uneventful and the histological study revealed that there was no variation in the healing process between the experimental and control groups.EnglishThesis