Dr. Abdul Azeez C. P.NEEMA CHERIAN2024-10-212024-10-212023-04-11https://krishikosh.egranth.ac.in/handle/1/5810215708The research was undertaken in goats with the objective of early diagnosis of pseudopregnancy using ultrasonography, estimation of serum progesterone concentration, treatment with three doses of cloprostenol sodium and evaluation of conception rate post treatment. The pseudopregnant does (Group I, n=8) diagnosed on day 60 post-breeding using B-mode ultrasonography (anechoic fluid filled uterus with hyperechoic trabeculae) were treated with three doses of 125µg of cloprostenol sodium (i/m) on the day of diagnosis (day 0), day 10 and day 20. The response to treatment were evaluated and compared with normal cycling does (Group II, n=8). Serum progesterone concentration was estimated on day 0, day of evacuation of uterine fluid, on days 10 and 20, day of induced oestrus, on days 21 and 60 post breeding in group I and on day of oestrus, on days 10, 21 and 60 post breeding in group II. Out of 254 goats screened for pregnancy, 15 does were identified as pseudopregnant (5.90%). Among various risk factors related to pseudopregnancy, significant relationship was identified with age (P=0.022), parity (P=0.047) and season (P=0.001). Ultrasonographic examination on different days revealed uterine wall thickness in pseudopregnant does reduced significantly (p <0.05) from day 0 (0.63 ±0.024 cm) to day 20 (0.58 ±0.025). Serum progesterone concentration (RIA) on day 0 and day 60 post breeding varied significantly (P < 0.01) between group I (2.73 ± 0.19 ng/mL) and group II (3.91± 0.19 ng/mL), respectively. The treatment protocol followed was sufficient to induce oestrus in 100 per cent pseudopregnant does. Conception rate varied non-significantly (P >0.05) between group I (50%) and II (75%). Therefore, it is recommended that pseudopregnancy can be diagnosed as early as 60 days post breeding and can be effectively treated using three doses of cloprostenol sodium 10 days apart.EnglishThesis