Sasikalaveni, A.Sujatha, P.L.Parthiban, M.Dhanapalan, P.Aruni, A. WilsonTANUVAS2019-07-162019-07-162014http://krishikosh.egranth.ac.in/handle/1/5810114937TNV_IJCBIM)3(2)_2014_362-368The Gyrase A gene of Mycobacterium tuberculosis has been shown to be responsible for the quinolone drug resistance. The Gyrase gene sequences we submitted in NCBI were retrieved. Accession No: EU835533, EU835534, EU835535. (Mtb1, Mtb2, Mtb3) and BLAST analysis revealed 95% identity with the available Mycobacterium tuberculosis Gyrase A gene. These sequences were also compared with the available Mycobacterium Gyrase gene of Indian isolates. The Gyrase A proteins were modelled using Modeller 9v3 version and the Ramachandran plot evaluation of all the models showed 94% in favourable region. The resistant strain (EU512947) reported from Coimbatore was also modelled and the three dimensional structure comparison of Mtb1, Mtb2, Mtb3 with the resistant Coimbatore isolate Gyrase coding protein was done using STRAP. The molecular similarity of the GyraseA protein of Mtb3 and EU512947 suggests all possible means of conversion this strain to a resistant Mycobacterial species.en-USVeterinary ScienceBioinformatics Centre and ARIS cellArticle