SURESH .K (MAJOR)LAKSHMI RANI .NDevi Prasad .VRAJA SHEKAR REDDY YERUVA MARIA2024-07-062024-07-062023-06https://krishikosh.egranth.ac.in/handle/1/5810211518The present study was undertaken to record the occurrence, clinical signs, haematological changes, radiographic findings, molecular detection or isolation and identification of bacteria from nasal swabs and to evaluate suitable therapeutic regimen in sheep affected with bacterial pneumonia. A total of 1991 sheep were screened for bacterial pneumonia of which 76 sheep exhibited the signs of pneumonia among which 52 sheep were positive for bacterial pneumonia making the overall occurrence of bacterial pneumonia in sheep to 2.61 per cent. Occurrence in relation to age, sex and month revealed highest percentage in <1 year, females and September, respectively. Clinical signs exhibited in ovine bacterial pneumonia included dullness to depression, fever, dyspnea, nasal discharges, inappetence to anorexia, tachypnea, coughing, congested conjunctival mucous membrane, isolation from flock and reluctance to lie down. Clinical examination of sheep in bacterial pneumonia revealed significant rise in temperature, respiratory rate and heart rate. Auscultation of lungs in ovine bacterial pneumonia revealed crackles, frictional rubs, wheezes and normal breath sounds. Confirmation of bacterial pneumonia was done either by molecular detection or by isolation and identification of bacteria. In the present study molecular detection done for Mannheima haemolyica, Pasteurella multocida and Mycoplasma ovipneumoniae by PCR showed an amplified product at 325 and 1022; 460 and 360 bp, respectively. In the present study isolation and identification of different bacteria revealed Mannheimia haemolytica, Klebsiella spp., Staphylococcus spp., Pasteurella multocida, Escherichia coli and Pseudomonas spp. and mixed infection of E. coli + Staphylococcus spp. and Klebsiella spp. + Pseudomonas spp. Radiographic examination revealed interstitial, mixed, alveolar and bronchial patterns, pleural effusions and no radiographic signs of pneumonia. Haematological examination revealed significant decrease in Hb, PCV, TEC and lymphocyte count while TLC, neutrophil, monocyte and eosinophil count were significantly increased. Therapeutic trial was taken up in 15 sheep affected with bacterial pneumonia caused by Mannheimia haemolytica and were randomly divided into 2 groups. Group I consisted of 8 sheep and were treated with ceftiofur sodium while Group II consisted of 7 sheep and were treated with marbofloxacin. Both the groups were treated in common with flunixin meglumine. Both the antibiotics proved to be efficacious in the treatment of pneumonia caused by Mannheima haemolytica but marbofloxacin was found to be more efficacious because the average clinical recovery time was lower.EnglishThesis