Sharma, S. K.Khurana, Anubhav2019-02-042019-02-042013-07-08http://krishikosh.egranth.ac.in/handle/1/5810093475The purpose of this study was to evaluate the neuroleptanalgesic combination of diazepam-butorphanol or acepromazine-butorphanol in propofol halothane anaesthesia. Twenty clients owned dogs of either sex were randomly divided into two groups DP (Diazepam-Propofol) and AP (Acepromazine-Propofol). All dogs were premedicated with Inj. Atropine sulphate @ 0.04 mg/kg b. wt. followed fifteen minutes later with Inj. Butorphanol tartarate @ 0.2 mg/kg b. wt IV. Subsequently after 10 minutes premedicated with Inj. Diazepam @ 0.5 mg/kg b. wt IV or Inj. Acepromazine maleate @ 0.015 IV followed by Inj. Propofol “till effect” IV for induction of surgical anaesthesia. After induction having achieved, the animals were immediately transferred to halothane in oxygen. Observations recorded in dogs included analgo-clinical observations, cardiovascular observations, haemodynamic observations, anaesthetic response and dose, pulmonary responses and haemato-biochemical observations at various time intervals. Average induction dose of propofol in DP group was 5.11 mg/kg and 4.89 mg/kg in DP and AP group respectively. Faster muscle relaxation and higher hypothermia was observed in AP group. No arrhythmia, tachycardia and fall in arterial blood pressure were observed in both the groups after induction. CVP, SPO2 and ETCO2 remained in physiological limits in both anaesthetic combinations. Significant respiratory depression occurred in both the groups after induction. Transient apnea was observed in three animals in DP group and two in AP group. Apneas were resolved without any intervention. Smoother induction and transfer were achieved by both combinations. Recoveries were smoother, faster and excitement free in AP group. Significant fall in PCV and TEC occurred in DP group in early phase whereas only PCV decreased significantly in AP group. Biochemical parameters were non significant in both the groups.ennullThesis