Kumar, AdarshRana, Yudhvir2023-03-042023-03-042023-02-04https://krishikosh.egranth.ac.in/handle/1/5810194782This study was executed in the clinical setup to document the effects of Rocuronium and its reversal by Neostigmine and Glycopyrrolate combination in Propofol-Isoflurane anaesthetized dogs. Rocuronium-induced neuromuscular blockade was applied to 21 clinical cases. Out of which 19 cases of orthopaedic surgeries and 2 cases of ovariohysterectomy were performed. Every animal included in this study was premedicated using Inj. Butorphanol tartrate at the dose rate of 0.2mg/kg b.wt I/M, then after a gap of 30 minutes Inj. Atropine sulphate was administered at the dose rate of 0.02mg/kg b.wt I/M, again after a gap of 10 minutes animal was premedicated with Inj. Diazepam at the dose rate of 0.5mg /kg b.wt. I/V and followed immediately by Inj. Propofol I/V(to the effect), for the induction of general anaesthesia. Soon after induction, the animal was maintained on a mixture of Isoflurane and oxygen. After the animal had stabilized, the relaxation of muscle was induced using Inj. Rocuronium at the dose rate of 0.5 mg /kgb.wt. I/V. Immediately IPPV was provided in volume control mode, with settings, a respiration rate of 15 breaths per minute, tidal volume at 10ml/kg body weight and inspiratory expiratory ratio as 1:2. Neuromuscular blockade was reversed at the first sign of asynchrony on the bellow and the multipara monitor. A single syringe combination drug Inj.Myopyrolate I/V having both Neostigmine and Glycopyrrolate was administered at the dose rate of 0.05mg/kg b. wt. and 0.01mg/kg b.wt respectively. Rocuronium caused the centring of the ocular globe gradually within 30 seconds. The central position of the ocular globe facilitates many kinds of surgical interventions and examinations in the eyes. During orthopaedic surgeries, the reduction of fractured ends became effortless. Easy reduction of the fracture without tissue trauma was observed. In ovariohysterectomy surgeries, the appropriate level of abdominal muscle relaxation further helped in the easy exteriorization of the ovarian stump. The onset time for Rocuronium was 17.64±1.10 sec and it provided muscle relaxation for 27.82 ± 0.72 min. The use of Rocuronium along with IPPV caused minimal alteration of the physiological parameters with no consequences clinically and thus can be considered a complication-free anaesthetic protocol for interventions demanding muscle relaxation.EnglishThesis