Sameena MehtabJoshi, Preeti2019-07-162019-07-162019-05http://krishikosh.egranth.ac.in/handle/1/5810114804The determination of CHO levels in blood is highly important because of an alarming rise reported in the rate of disorders due to abnormal levels of blood CHO. CHO sensing material estimation based on WC and PIN co-polymerization technology was synthesised. SSE have been modified by electroactive film of PIN with varying the concentration of WC 5, 10 and 15% (%, w/w) and SPS was used as a binder. DPV was performed for the EC quantification of CHO and electrochemical stability was investigated through EIS and potentiodynamic polarization in KOH (1.0 M). DPV with scan rate 30 to 50 mV/s and potential range 0.15 to 0.65 V were studies to optimize the EC parameters. The LOD obtained for [I], [II] and [III] are 7.63 × 10-6 molL-1, 10.37 × 10-6 molL-1 and 1.23 × 10-6 molL-1 and LOQ are 23.13 × 10-6 molL-1, 31.42 × 10-6 molL-1 and 3.74 × 10-6 molL-1 respectively. It was found that the correlations between the CHO concentration and peak current were in linear relation with micro molar sensitivity. DPV and EIS data reveals that [III] imparts the best detection limit and stability as compared to the bare, [I] and [II]. Tafel data also exhibits the improved corrosion resistance of [III] than [I], [II] and SSE. The present investigation reveals a fast, sensitive and low cost WC/PIN nanocomposite modified EC sensor to detect CHO. The developed sensor can also be employed for the CHO estimation in biological systems.ennullThesis