Priyadarshini Swain, PriyakaRaja, ATANUVASKumanan, KPalanisammi, A2019-07-062019-07-062016http://krishikosh.egranth.ac.in/handle/1/5810113135TNV_TH_2016_MVM14002Recent concerning facts of lBV; at Coronaviridae family Gammacorona virus has proved as a major pathogen which threatens the poultry industry, and causes piles of economic losses worldwide due to loss of productive performance of both egg and meat-type chickens. The virus causes mainly respiratory, reproductive and renal diseases in chicken. Despite intensive vaccination efforts using attenuated live and killed vaccines to prevent the disease, outbreaks of IB still occur frequently because of infections with emerging field strains that differ serologically from vaccine strains. Hence, IBV vaccines must induce broad protection against different IBV serotypes for wider acceptance by poultry industry.enVeterinary ScienceEFFECT OF COMPUTATIONALLY OPTIMIZED BROADLY REACTING NUCLEOPROTEIN ON IMMUNE RESPONSE TO AVIAN INFECTIOUS BRON CHITIS VIRUSThesis