Kumar, Dr. DharmendraVERMA, ABHISHEK2021-11-082021-11-082019https://krishikosh.egranth.ac.in/handle/1/5810177885Since time immemorial man has used various parts of the plants in treatment and prevention of many ailments. Studies on wound healing property of Aloe vera and Tridex procumbens in terms of gross, histological and histopathological changes were done. Twenty four male calves aged between 6 month to 1 year having wounds were randomly divided in four groups and were treated with Normal saline, Povidone Iodine, Aloe vera and Tridax procumbens in group A, B, C and D respectively. An incidence of 7.9 % of wound in all species was reported with highest cases of wound in canine followed by bovine and caprine. Males were having more cases of wound and maximum cases were observed in the age group of 1-3 years. Highest incidence of wound was recorded on limbs followed by trunk and maximum of it was lacerated wound. Presentation of case following occurrence of incidence was too observed and it was found that most of the cases were presented between 3-5 days after occurrence of incidence. General clinical parameters like temperature, pulse, respiration and haematological values fluctuated within the normal physiological limit. The data obtained were in accordance with Basha et al. (2011). Grossly on 0th day almost all the wound appeared lustreless whitish yellow and contaminated which later on converted to pinkish, reddish, reddish brown and brownish white on 5th, 10th, 15th and 20th post treatment day however, colours were more prominent in case of group B, C and D. Exudation gradually reduced in all cases, however its complete absence was observed on 10th post-treatment day in group B, C and D compared to group A, where it was observed till 15th day. Pain too decreased gradually in all groups but its complete absence was observed on 10th post-treatment day in group C. Degree of pain in group B and D on 10th day was meagre compared to group A, where it was more prominent. A gradual decrease in wound area, almost in all group was observed with maximum wound contraction in group C on 15th, 20th and 25th post-treatment day. Comparison between group B and D revealed higher wound contraction on 10th, 15th and 20th day in group B but it was superseded by group D on 25thday. However, data of group B and D did not vary significantly. Least wound contraction was observed in group A throughout the study period. Histological section of 5thpost-treatment day revealed heavy infiltration of neutrophils and macrophages accompanied with serofibrinous exudates, haemorrhage and necrotic foci in wounds of group A, but these infiltration was of moderate nature in group B, C and D. Evidence of meagre amount of angioblasts and scant fibroblasts were too observed in the deep layer of dermis of wound in all the groups, however its density was more in group B, C and D as compared to group A. On 10th post – treatment day the more denser fiboblast cells than the previous day was observed and its density was more in group B followed by C, D and A. Histological findings on 15th day revealed dense collagen fibres in group C followed by group B, D and A. There was a neck to neck similarity in findings of group B and D. Elastic fibres were too discernible at this stage in all groups ,however its density was more in group C followed by group D, B and A. On 20th day abundant collagen fibres and moderate amount of elastic fibres was observed in all groups but its density was more in group A. Keratinisation of the epidermis was too observed at this stage with maximum density in group C. Slide of 25th day showed thick layer of epidermis almost covering the entire wound area in all the groups but maximum well differentiated epidermis with close rete pegs extending uniformly was observed in group B, C and D with maximum differentiation in group C and least in group A. From the above findings it can be concluded that all the medicaments facilitates wound healing but Aloe vere masks the healing of all other groups at each stage.EnglishnullThesis