Dr. Hemant DadhichRENU2022-05-132022-05-132021https://krishikosh.egranth.ac.in/handle/1/5810184711In the present investigation, detailed necropsy was performed on 362 sheep irrespective of age, sex and breeds. Out of these, 123 sheep suspected for enterotoxemia were processed for molecular confirmation of Clostridium perfringens type D from intestinal contents by using PCR. After conducting PCR, 66 sheep found positive for Clostridium perfringens type D which was further processed for histopathological examination. An overall incidence of enterotoxemia infection in sheep was recorded as 18.23 percent. The various forms of kidney lesions were classified as glomerular necrosis (48.48 percent), renal tubular necrosis (74.24 percent), fatty changes (3.03 percent), congestion and oedema (59.09 percent), haemorrhages (68.18 percent), inflammatory cells infiltration (95.45 percent), vacuolar degeneration (9.09 percent), protein cast (1.51 percent), and cloudy swelling (10.60 percent). The various forms of liver lesions were classified as necrosis (19.69 percent), congestion and oedema (81.81 percent), inflammatory cells infiltration (87.87 percent) and fatty changes (3.03 percent). The various forms of intestine lesions were classified as congestion and oedema (90.09 percent), haemorrhages (19.69 percent), necrosis (71.21 percent), inflammatory cells infiltration (89.39 percent) and goblet cells hyperplasia (6.06 percent). The various forms of lungs lesions were classified as congestion and oedema (96.96 percent), haemorrhages (69.69 percent), interstitial pneumonia (65.15 percent), and pulmonary emphysema (16.66 percent). The various forms of heart lesions were classified as congestion (72.72 percent), haemorrhages (69.69 percent) and inflammatory cells infiltration (84.84 percent).EnglishThesis