Chauhan, SonuSmriti2023-04-222023-04-222022https://krishikosh.egranth.ac.in/handle/1/5810196575Two Schiff base p-anisalidene-o-aminophenol(ANSAP) and p-chlorobenzylidene-o-aminophenol(CBAP) was synthesized by the reaction of 2-aminophenol with p-anisaldehyde and p-chlorobenzaldehyde, respectively. Manganese(II), Iron(II), Cobalt(II), Nickel(II) and copper(II) complexes of these Schiff bases were also prepared by using conventional reflux method. All the newly formed compounds were characterized by using various spectroscopic techniques like elemental analysis, molar conductance, FT-IR, 1H NMR and UV-Visible. The data from spectral studies revealed that both the Schiff base ANSAP and CBAP act as a neutral bidentate ligand. All the synthesized complexes were tested for their antibacterial activity against Xanthomoans sp. and Staphylococcus aureus VTCC BAA20. Antifungal activity against Fusarium oxysporum sp. lycopersici and Candida albicans sp. was also carried out using agar well diffusion method. It was found that the Schiff bases had no or moderate antimicrobial activity while their complexes showed significant antimicrobial activity. Maximum Xanthomoans sp. growth was inhibited by the iron, nickel, copper complexes of ANSAP and manganese, nickel complexes of CBAP. Maximum Staphylococcus aureus VTCC BAA20 growth was inhibited by the copper complex of ANSAP and nickel complex of CBAP. Maximum Fusarium oxysporum f. sp. lycopersici growth was inhibited by the iron, cobalt, nickel complexes of ANSAP and manganese, iron, cobalt, nickel, copper complexes of CBAP. Maximum Candida albicans growth was inhibited by the manganese, iron, cobalt complexes of ANSAP and manganese, iron, cobalt, nickel, copper complexes of CBAP.EnglishThesis