SURESH KUMAR, R.V(MAJOR)HARA GOPAL, VSRILATH, ChPENCHALAIAH, P2018-12-042018-12-042006-04http://krishikosh.egranth.ac.in/handle/1/5810085233THESESABSTRACT: Twelve cattle undergoing amputation of horn procedures were randomly divided in to two groups. In group I animals surgery was performed following standard procedure and in group I1 meloxicam was administered at the dose rate of 0.2 mg per kilo gram body weight intravenously 30 minutes before anesthesia and surgery. Preemptive analgesic effects were evaluated by physiological, haematological, pulse oxymetric, and biochemical studies. Meloxicam did not alter rectal temperature and pulse rate values in the present study. Though the respiratory rates showed the significant rise in both the groups these were within the normal physiological range. Pulse oxymetric studies revealed no sigruficant changes in Sp02values in both the groups. Total erythrocyte values showed sigmficant reduction in group I whereas the changes were not sigruficant in meloxicam treated group. Both the groups showed leukocytosis, neutrophilia, and lymphocytopenia, more sigruficantly in group I compared to group 11. Haemoglobin and packed cell volume values were sigruficantly reduced in group I compared to group LI. Biochemical parameters like cortisol, C-reactive protein and glucose were sigruficantly increased in group I where as meloxicam treated animals showed non sigruficant fluctuations. In conclusion meloxicam a selective COX-2 Inhibitor could be used satisfactorily as a preemptive analgesic to reduce post operative pain in amputation of horn in cattle.ennullThesis