Das, M. R.Dash, SachinPatra, R. C.Nath, IndramaniBehera, P.C.Panda, S. K.Senapati, S. K.2022-01-212022-01-212020https://krishikosh.egranth.ac.in/handle/1/5810181118Th-6061Present clinico epidemiological investigation of 80 no of dogs showing the clinical symptoms of lethargy, fever, anorexia, vomition, bloody diarrhoea with foul smell were noticed in CPV infection through PCR, HA and Kit Ag test method of diagnosis on the basis of age, sex and breed. Out of them, 64 80% no of dogs were found positive for CPV infection. The study revealed that (80%) cases were found positive by PCR,65% by HA and 61.25% by Kit Ag test method, where the youngs pups between the age of 4-12 months were found more susceptible to CPV infection as compared to other two age groups viz.1-3 months and more than 12 months of age. Further male dogs were found more prone to infection than female counterpart. Similarly, breed wise study revealed that between two breed, exotic breeds were more prone to CPV infection than indigenous breeds, however large breeds were found to be more affinity to infection than other two varieties viz. small and medium breeds of dogs. By culture of faecal samples from affected dogs, it was found that E. coli bacterias were accounted for the highest no of cases (43.75%) and signifying its dominance over other bacteria causing secondary bacterial infection. In vitro microbial sensitivity test was performed by taking the samples and the highest degree of sensitivity was observed to Ceftriaxone+ sulbactam (85%) followed by Amikacin (78.75%) Ampicillin + Sulbactam (73.75%), Cefoperazone + sulbactam (53.75%). Significant variation was found both in haematological and serobiochemical parameters before treatment by both conventional and conventional with hyper immune serum method with respect to age, sex and breed wise, but no variation was observed in both parameters after treatment by only conventional with hyper immune serum method. Inspite of aggressive therapy, the CPV infected dogs showing the symptoms of profuse vomition with foul smelling bloody diarrhoea were treated with parenteral fluid therapy, broad spectrum antibiotics, anti-emetics, anti-haemorrhagic and canine parvovirus anti serum with other supportive therapy. After recovering the survivility rate (85.71%) was found more in dogs above 12 months age group than other two groups viz.1-3 months (79.16%) and 4-12 months (73.03%) of age. Similarly, it was noted that the survival rate (90.62%) was more in dogs in CPV infection those were treated with conventional with hyper immune serum method than only conventional method of therapy (65.62%).EnglishThesis