Ramya, RMadhanmohan, MNagarajan, TTANUVAS2019-12-112019-12-112018-03http://krishikosh.egranth.ac.in/handle/1/5810137435TNV_IJVM_2018_73(1)3-14Rabies is a fatal zoonotic disease of serious public health and economic significance around the globe. It is caused by a bullet-shaped virus belonging to the genus Lyssavirus of family Rhabdoviridae. India is one of the few rabies endemic countries that continue to face problems associated with large number of human deaths due to rabies. In the developed countries, human rabies has dramatically declined during the past 50 years as a direct consequence of routine vaccination of pet animals. However, wildlife rabies has emerged as a major threat. Therefore, rabies is preventable by controlling rabies in both wildlife and domestic animal populations. Vaccination remains the only viable alternative for prevention, control and eradication of rabies in both developed and developing countries. Since Louis Pasteur’s first attempt to produce rabies vaccines, a number of approaches have been evolved from the usage of nervous tissue vaccines to the novel recombinant vaccines. However, to date Rabies remains a global health threat despite it being a vaccine-preventable disease. This status clearly indicates a demand for more effective and economic rabies vaccines. The protein subunit based vaccines consisting the immunogenic components of a virus can be a methodology to produce the affordable, safe and immunogenic rabies vaccines without the necessity of handling live rabies virus.enVeterinary ScienceArticle