Dr. D. J. GhodasaraPAWAR AALAP N.2017-06-232017-06-232009http://krishikosh.egranth.ac.in/handle/1/5810022938Rosuvastatin is among of the most effective treatment of hyperlipidemia and dyslipidemia by providing an important and effective approach for lipid lowering agents. Thiazolidinediones (rosiglitazone and pioglitazone) are most commonly prescribed in patients with type 2 diabetes mellitus to lower blood glucose levels. The present research work was conducted to evaluate the repeated dose toxicity of rosuvastatin and thiazolidinediones (rosiglitazone and pioglitazone) in Sprague Dawley male rats. The animals were divided in 7 different groups with 6 male animals in each group. The groups I, II, III, and IV were administered vehicle control (0 mg/kg), rosuvastatin (50 mg/kg), rosiglitazone (80 mg/kg), and pioglitazone (300 mg/kg) in individual treatment groups respectively. The groups V, VI and VII were treated in different combinations with rosuvastatin (50mg/kg) + rosiglitazone (80mg/kg); rosiglitazone (40mg/kg) + pioglitazone (150mg/kg) and rosiglitazone (80mg/kg) + pioglitazone (300mg/kg) respectively by oral dosage for 28 days.enVeterinary PathologyStudyThesis