Dr. Arun GeorgeREMYA KRISHNA U. S.2024-08-062024-08-062023-03-23https://krishikosh.egranth.ac.in/handle/1/5810212931The present study was undertaken to screen the dogs brought to TVCC, Mannuthy and UVH, Kokkalai for arrhythmia associated with respiratory (GroupI), renal (Group II), and gastrointestinal (Group III) diseases and to evaluate the electrocardiographic and biochemical changes in the study population. Twenty animals were selected in each group for detailed study. The occurrence of arrhythmia in group I, II and III were 46.5, 51.2 and 42.6 percent, respectively. Pneumonia and pleural effusion were the major clinical conditions noticed in group I animals. Sinus arrhythmia followed by first-degree atrioventricular (AV) block and wandering pacemaker were the common arrhythmia and a significant increase in P-R interval with normal haematobiochemical parameters were noticed. Potassium, magnesium and calcium were found to have no significant difference as compared to the control group and also CK-MB had no significant variation. In group II, arrhythmia was more predominant in animals with chronic kidney disease (CKD) followed by acute kidney injury (AKI). Sinus arrhythmia followed by first-degree AV block and wandering pacemaker were the common arrhythmia observed. A significant increase in R-R interval and a decrease in heart rate was noticed. The haemato-biochemical analysis revealed anaemia, leukocytosis with neutrophilia, elevated blood urea nitrogen (BUN) and creatinine level. A significant increase in magnesium was noticed in group II whereas calcium, potassium and CK-MB had no significant variation on comparison. A significant positive correlation was noticed between hemoglobin, volume of packed red cells (VPRC) and red blood cell count (RBC) with T amplitude and creatinine and BUN with corrected Q-T interval. A significant negative correlation was noticed between VPRC, RBC and haemoglobin with the corrected QT interval. In group III, arrhythmia was predominant in parvoviral enteritis and sinus arrhythmia followed by wandering pacemaker and left bundle branch block were predominant. A significant decrease in P amplitude was evident and haemato-biochemical analysis revealed anaemia, decreased BUN and elevated creatine kinase-MB (CK-MB) and alkaline phosphatase (ALP). Serum potassium, calcium and magnesium had no significant variation as compared to the control group. A significant positive correlation was noticed in RBC, VPRC and haemoglobin with T amplitude, T duration and corrected QT interval and a negative correlation between CK- MB and P amplitude. These findings in the present study might help in the early diagnosis and immediate treatment of arrhythmia associated with these conditions.EnglishThesis