Mekala, P.Jagadeeswaran, A.Arivuchelvan, A.Sethilkumar, P.Nanjappan, K.Krishnamurthy, T.R. GopalaTANUVAS2018-04-132018-04-132017-07http://krishikosh.egranth.ac.in/handle/1/5810043412TNV_PNAS_2017_87(3)679–683Enrofloxacin was administered to commercial broiler chicken of 6 weeks of age at 10 mg kg-1 as oral bolus and pulse dose to two groups of twelve birds each. Blood was collected at predetermined time interval and plasma samples were analyzed for enrofloxacin concentration by using HPLC. Mean plasma concentration was significantly higher in oral bolus dose up to 2 h and at 48 h. In both the groups enrofloxacin concentration was above 0.30 lg mL-1 up to 24 h. Pharmacokinetic parameterswere calculated by non compartmental analysiswhich revealed significant increase in AUC0–? (25.35 ± 1.92 vs. 19.66 ± 1.68 lg h mL-1) and t1/2b (10.63 ± 0.35 vs. 8.70 ± 0.74 h) in oral bolus dose when compared to pulse dose. There was no significant difference in other pharmacokinetic parameters such asMRT,MAT,Vd area/F,Vdss/F,ClB/F,Cmax and tmax. Hence it can be concluded that enrofloxacin administered to broiler chicken at 10 mg kg-1 every 24 h as pulse dosewill result in better clinical efficacy at par with oral bolus dose.enVeterinary ScienceArticle