ADILAXMAMMA, K(MAJOR)VEHKATESWARLU, UESWARA PRASAD, PSUDHAKARA RAO, P2018-08-232018-08-232005-12http://krishikosh.egranth.ac.in/handle/1/5810067184THESESABSTRACT: Present study was conducted to assess the hypolipidemic action of aqueous and alcoholic extracts of Tinosporn cordifoolia roots and compared the same with that of lovastatin and Vitamin E, on biochemical and histo-pathological patterns in diet induced hyperlipidemic rats. Forty-eight male albino rats weighing around 150 gm were divided into 6 groups of eight in each. Group I served as control. Group 11,111, IV, V and VI received experimental hyperlipidemic diet. Group 111 received lovastatin @ 30 mgKg body weight. Group IV, V received aqueous and alcoholic extracts of Tinospora cordiyoIia roots respectively @ 5g/ Kg body Wt. Group VI received vitamin E @ 60 mg /Kg body Wt. The serum lipid parameters w,HD L, LDL and TG] and erythrocyte antioxidant enzymes [GPx, GSH- R] were monitored at day 14,28 and 42. At the end of day 42, animals were sacrificed and liver and aorta samples were collected for histo-pathological examination. Administration of hyperlipidemic diet resulted in increase of lipid parameters like TC, LDL, and TG and decrease of HDL The erythrocyte antioxidant enzyme [GPx, GSH- R] levels of whole blood were significantly pSO.05] increased in T. cordifolia aqueous and alcoholic extracts treated groups. Both alcoholic and aqueous extracts of T cordifoolia ameliorated the hyperlipidemic effects of group I1 by restoring the biochemical [TC, HDL, LDL and TG] and histopathological changes to normal. Hypolipidemic effect of groups IV and V was similar to group 111. Vitamin E treated group significantly increased the levels of erythrocyte antioxidant eniynes but showed less action on lipid parameters. It is concluded that aqueous and alcoholic extracts of T.cordifoolia roots could act as hypolipidemic agents in diet induced hyperlipidemic rats.ennullThesis