B.K.RoyHemant Kumar Panday2024-07-082024-07-081999https://krishikosh.egranth.ac.in/handle/1/5810211601. The mean free CSmax (26.28±0.067 ug/ml) of DMZ was evidenced at 5 min declined slowly and CSther was maintained till 48 hr. after single i.v. dose (8mg/kg) administration in buffalo calves.. 2. It was evidenced that DMZ was rapidly absorbed after i.m. administration with a tmax at 30 min. 3. The mean peak free serum concentration (8.41±2.43 µg/ml) of DMZ was obtained at tmax of 30 min. after single i.m. dose (16mg/kg) administration. 4. The overall serum concentration of DMZ obtained after single i.m. injection was lower than its single dose i.v. administration. 5. The possible reason for attainment of lower DMZ serum concentration after i.m. administration has been explained with the help of results obtained for kinetic variables. 6. The Cumax of DMZ was observed at 1 hr. (240.00+1.77 µg/ml) and 3 hr. (286.25 +4.10µg/ml) after single dose i.v. and i.m. administration respectively. 7. Urinary excretion of DMZ was dependent on the amount of drug available in systemic circulation which indicated that this compound followed first-order elimination kinetics in buffalo calves.EnglishThesis