Dayal Doss, D.SOWMYA, M.2018-07-242018-07-242017-11-20Th-11879http://krishikosh.egranth.ac.in/handle/1/5810061654Present investigation of screening for anti-diabetic compound corosolic acid and analysis of biochemical constituents were carried out in selected medicinal plants such as Lagerstroemia speciosa (Banaba), Psidium guajava (Guava), Costus igneus, Costus pictus (Spotted ginger, Insulin plant), Thymus vulgaris (Thyme), Catharantus roseus (Periwinkle), Rosmarinus officinalis (Rosemary), Lavandula angustifolia (Lavender), Mentha piperita (Peppermint) and Ocimum basilicum (Sweet basil). Corosolic acid also referred as “Glucosol” reported to have active reduction in blood glucose level. Corosolic acid is reported to have a vital role as anti-diabetic and anti-obesity agent. Selected medicinal plants were screened for potential antidiabetic drug corosolic acid by HPLC technique. In the present study methanolic leaf extracts of Rosmarinus officinalis (338.6 mg/100 g dw) shown to have higher amount of corosolic acid as compare to other selected medicinal plants. Biochemical constituents viz., total protein, phenols, tannins, flavonoids and antioxidants were analyzed. Rosmarinus officinalis shown to have higher amount of flavonoids (2413.63 mg/ 100g fw) and antioxidants (837.1 mg/100g fw). Catharantus roseus reports higher amount of total proteins (3.24 g/100 g fw) whereas Ocimum basilicum recorded highest phenols (2485.36 mg/100 g fw). The leaves of Lagerstroemia speciosa found to have higher tannin content (3927 μg/100 g fw). In the present investigation corosolic acid was screened using HPLC, for the first time HPLC reports the presence of corosolic acid in leaf samples of Rosmarinus officinalis. The leaves of Rosmarinus officinalis can be good source of anti-diabetic compound ‘corosolic acid’ and antioxidants.ennullThesis