D. DILIPKUMARV. M. SALUNKEB. V. SHIVAPRAKSHVENKATGIRI2021-03-122021-03-122019-06https://krishikosh.egranth.ac.in/handle/1/5810162329The study was carried out to evaluate the feasibility of Romifidine, Dexmedetomidine and Xylazine sedation for Ketamine-Isoflurane general anaesthesia for various surgeries in cattle. The study was carried out in 18 clinical cases of cattle presented for various major surgical procedures randomly divided into three groups consisting of six cattle in each group. The animals of Group I were administered with Romifidine (10 µg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg, I/V) and maintained with Isoflurane (1-2%). The animals of Group II were administered with Xylazine hydrochloride (0.1 mg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg, I/V) and maintained with Isoflurane (1-2%). The animals of Group III were administered with Dexmedetomidine (2.5 µg/Kg, I/V) followed by Ketamine hydrochloride (3 mg/Kg, I/V) and maintained with Isoflurane (1-2%). Faster induction time, early onset of sedation, early recovery time to regain sternal position and to assume standing position were noticed in cattle premedicated with romifidine than cattle premedicated with Dexmedetomine and Xylazine for Ketamine-Isoflurane general anaesthesia. Romifidine as a premedicant provided better analgesia, degree of sedation and muscle relaxation compared to dexmedetomidine and Xylazine whereas, after induction of general anaesthesia it was excellent in all the groups. Respiratory depression, bradycardia and decrease in mean arterial pressure were more severe in cattle premedicated with Romifidine and Xylazine when compared to cattle premedicated with Dexmedetomidine for Ketamine-Isoflurane anaesthesia. Heamato-biochemical parameters fluctuated within normal limits. Hence in present study we can conclude that, Romifidine was more powerful sedative than Xylazine and Dexmedetomidine, during Ketamine-Isoflurane induced general anaesthesia in cattleEnglishThesis