Tresamol, P.V.MINI, K.V.2019-06-282019-06-282015KVASU REFERENCE CITATIONhttp://krishikosh.egranth.ac.in/handle/1/5810110454Post-vaccination sero-monitoring is a vital component of any intensive vaccination strategy. The main aim of the study was to assess the sero-conversion following FMD vaccination in pre-sensitized adult cattle using Sd-LPB ELISA. In addition, immune response in primi-vaccinated calves against oil adjuvanted trivalent FMD vaccine was also assessed. Differentiation of immune response due to vaccination and infection was studied using 3ABC NSP ELISA. Dynamics of maternally derived antibody in new born calves was also monitored. Adult animals responded well to FMD booster vaccination and maintained protective immunity up to six months. Sero-positivity to NSP 3ABC in apparently healthy animals corroborated persistence of subclinical infection within vaccinated herd. Maternally derived antibody found to persist in the system of colostred calves for up to the age of five months and its interference toward induction of primary immune response to vaccination was further documented. The efficacy of a booster dosage in calf-hood vaccination was evaluated and found to drastically improve the immune response. Carrier status could be detected among FMD convalescent cattle even six months post-outbreak, with higher molecular prevalence of serotype O in their oropharyngeal secretion. Presence of previous exposure to infection, subclinical infection or carrier state did not significantly influence the sero-conversion to subsequent vaccination.ennullThesis