Rath, S NSahoo, Maheswata2017-01-052017-01-052015http://krishikosh.egranth.ac.in/handle/1/94726A serious Influenza pandemic infection has rapidly spread across the world since 2009 causing nearly 300,000 deaths globally within the first year of the pandemic. In 2014 & 2015, the swine flu pandemic hits again with increased rate of reported cases. H1N1, a swine influenza virus is a known causative agent of swine flu. The entire Influenza A virus genome contained eight RNA segments such as Matrix protein, Hemagglutinin (HA), Neuraminidase (NA), Nucleocapsid protein, Polymerase PB1, Polymerase PA, Polymerase PB2 and Non-structural protein. Out of 8, two proteins HA and NA are mainly important for H1N1. There are many plant products traditionally used for treatment of influenza infection among them 13 natural compounds namely Theaflevin, Curcumin, Alicin, Eugenol, Menthol, Carvacrol, Catechin, Ajoene, Ursolic acid, Tinosporone, Coumarin, Baicalin and Andrographoloid were reported to act against human influenza flu. In this study, we performed docking analysis to explore the molecular interaction between those selected plant originated active compounds against important proteins of H1N1. High throughput protein models of H1N1 HA and NA proteins were predicted to anticipate the interaction mechanism of these proteins with these natural inhibitors using structure-based drug designing approach. Among 13 natural compounds, theaflevin, extracted from leaves of tea plant, was observed to inhibit H1N1 proteins with lowest binding energy. Further, docking analysis besides helping in silico validations of natural compounds also helped elucidating the molecular mechanism of inhibition of important proteins of H1N1 proteins.enInfluenza ,Hemagglutinin ,Neuraminidase ,H1N1Thesis