Gupta, M. P.Kumar, Sunil2019-02-282019-02-282003http://krishikosh.egranth.ac.in/handle/1/5810097383The present study was carried out to assess the Epidemiological,Haematobiochemical observations and efficacy of Oxyclozanide and Triclabendazole against Paramphistomosis in Buffaloes (Bubalus bubalis) in bet area in and around Ludhiana district and total of 500 random buffalo faecal samples were collected. The overall coprological prevalence of paramphistomosis was found to be 23%. The haematological profiles of buffaloes with paramphistomosis revealed anemia, leukocytosis, neutrophilia and eosinophilia as compared to healthy control animals. Serum protein profiles of infected buffaloes showed hypoproteinemia, hypoalbuminemia and decreased A/G ratio. Mineral profiles reflected significant reduction in iron concentration in infected buffaloes. The eggs per gram(EPG) were elevated in infected buffaloes and found to be 770±110.5(Infected and Treated Group C) and 680±170.5 (Infected and Treated Group D). However, after treatment with oxyclozanide @ 1 gm/100 Kg bwt (orally) and triclabendazole @l0m1/50 Kg bwt (orally), the infected buffaloes showed in recovery clinical signs and their haematological and biochemical profiles improved. On the basis of reduction eggs per gram on successive days of observation, it was concluded that oxyclozanide was much more (100% at day 28th after treatment) efficient against paramphistomes in buffaleos than triclabendazole, which showed very little efficacy (55.8%) against paramphi stomes.en-usThesis