Thaker, A. M.Barot, Deepak K.2018-06-072018-06-072002http://krishikosh.egranth.ac.in/handle/1/5810049940The present study was conducted to determine the pharmacokinetics of enrofloxacin after single dose intravenous and oral administration in White leghorn hens. Plasma concentrations of enrofloxacin and its metabolite ciprofloxacin were determined by High Performance Liquid Chromatography (HPLC). After intravenous administration, the plasma concentration- time curve was characteristic of a two compartment open rnodel whereas, it was best fitted to one compartment open model following oral administration. Following single dose (10 mg/kg of body weight) intravenous administration of enrofloxacin, the therapeutically effective plasma concentration (>=0.10 µg.ml-1) was maintained for up to 12 hours."The drug was rapidly and extensively distributed [t1/2α: 0.22 ± 0.04 h ; Vd(area); 2.14 ± 0.15 1 kg-1 ] and rapidly eliminated (t1/2β; 4.52 ± 0.52 h) from the body with a clearance rate (CIB) of 5.59 ± 0.27 ml min-1 kg-1. An active metabolite, ciprofloxacin was detected in plasma with peak concentration of 0.30 ± 0.06 µg.ml-1 at 2 hours following intravenous administration of enrofloxacin. Enrofloxacin gets de-ethylated to ciprofloxacin and the metabolic conversion accounts for 7.06 percent of the parent drug. The AUC and MRT values were 2.11 ±0.14 µg.h-1ml-1 and 10.36 ± 0.52 hours, respectively.enVETERINARY PHARMACOLOGYA STUDYThesis