Dr. Sudheesh S. NairJAYAKRISHNAN V2024-09-282024-09-282023-03-23https://krishikosh.egranth.ac.in/handle/1/5810215128The present study was conducted for clinical evaluation of a multimodal anaesthetic protocol using butorphanol-dexmedetomidine-midazolam-ketamine isoflurane and lignocaine continuous rate infusion in six cross-bred female cattle with mean weight of 333.00 ± 46.32 kg. Pre-anesthetics used were butorphanol and dexmedetomidine which were administered intravenously at dose rates of 0.05 and 1 µg/kg body weight, respectively. Moderate quality sedation was achieved within a mean time of 7.67 ± 1.08 minutes. Ketamine and midazolam were intravenously administered at dose rates of 4.0 and 0.2 mg/kg body weight respectively, to induce anaesthesia. Excellent quality induction was achieved within a mean time of 5.83 ± 1.11 minutes. Isoflurane was used to maintain anaesthesia after endotracheal intubation, at a concentration of 1.056 ± 0.97 per cent concentration in 100 per centoxygen using a large animal anaesthesia machine. Simultaneously, intravenous lignocaine was administered at a bolus dose of 2 mg/kg followed by a constant rate infusion of 3 mg/kg body weight using a volumetric infusion pump. Isoflurane sparing effect of intravenous lignocaine reduced the required per cent of isoflurane. The third plane of surgical anaesthesia was maintained and various surgical procedures were done. During the course of anaesthesia, the differences in heart rate, rate of respiration and rectal temperature were found to be statistically non-significant. Simultaneously, a significant rise in capillary refill time was also noticed. Haematological, serum biochemical, blood gas and electrolyte parameters recorded non-significant changes. Recovery was smooth and the mean time required to exhibit the first voluntary reflex,assume sternal recumbency and stand up unassisted following the cessation of isoflurane anaesthesia were 7.50 ± 1.82 minutes, 15.17 ± 5.16 minutes and 35.33 ± 17.04 minutes respectively. Other than the mild regurgitation of ruminal fluid in an animal, no anaesthetic complications were noticed.EnglishThesis