Dr. DILIPKUMAR, DSWAROOP, G. L2021-03-122021-03-122019-08https://krishikosh.egranth.ac.in/handle/1/5810162292The study was conducted to evaluate xylazine – ketamine and dexmedetomidine – ketamine bolus induction intravenously and maintenance by isoflurane anaesthesia in dogs for various surgeries. The study was conducted in 12 clinical cases presented to VCC, Bidar. Twelve animals were randomly divided into two groups viz., Group-I and group-II consisting of six animals in each group. All the animals in two groups were atropinised at the rate of 0.045mg/kg via., intramuscularly. Group-I animals received xylazine – ketamine bolus (1 mg/kg and 10 mg/kg respectively) intravenously, in the Group-II animals dexmedetomidine – ketamine (10 µg/kg and 10 mg/kg respectively) was administered intravenously, after dogs reaching surgical plane of anaesthesia endotracheal intubation was done for isoflurane (1-2 %) anaesthesia as a maintenance administration in all the animals of two groups. Anaesthetic combinations were compared by clinicophysiological, haemodynamic and hematobiochemical observations. Group II dogs showed quicker and smooth induction time and prolonged recovery than group I. Degree of analgesia and muscle relaxation were greater in group I than group II. Physiological parameters like rectal temperature showed no significant variation in two groups. Respiratory rate and heart rate had significant difference in two groups which was transitory in nature, hence two combinations were well tolerated by the dogs. Haemodynamic observations had varied significantly in two groups. Haematological observations revealed that slight changes were observed in two groups of dogs. Biochemical parameters were varied significantly in two groups. Hence, xylazine – ketamine bolus and dexmedetomidine – ketamine bolus combination provides cardiac, thoracic and abdominal relaxation, there by kept the animal in good surgical plane of anaesthesia. However, good analgesia and excellent muscle relaxation were observed in xylazine-ketamine bolus induction and isoflurane maintenance anaesthesia in dogsEnglishThesis