Dept. of Veterinary Public Health2021-11-022021-11-022019https://krishikosh.egranth.ac.in/handle/1/5810177669As per OIE 60% of known human diseases are having the origin of the animal source . The world wide incidence of zoonoses is of great concern more so over for developing countries. At global landscape, we are facing emergence and re-emergence of zoonotic diseases. The pandemic of animal origin diseases like swine flu, avian flu, SARS etc have its own impact, along with the threat of bioterrorism. Disease outbreaks and zoonotic nature of diseases in developing countries like India have a very devastating socio-economic impact on the farmers, persons involved in related occupa tion and the people consuming animal products and byproducts. The present scenario of climate change, drug resistant microbes and immune escape mutants, are evolving at faster rate and leading to these outbreaks. The occurrence of these outbreaks indicates the insufficient efforts for early di agnosis and prevention, and lack of optimum prophalytic measures. At present, the turnaround time between referring clinical samples to concern laboratories and to get the confirmatory report is long, by that time the infection spreads to large area leading to an outbreak.. In recent years, a One Health (OH) approach to manage endemic and emerging/ re-emerging zoonotic diseases has been promoted by international human and animal health agencies. In Indian context, in order to achieve OH, owing to shared interests in research activities pertaining to the area of zoonoses, Indian Council of Agricultural Research (ICAR) in the year 2014-15 has funded Niche Area of Excellence project titled “Centre for Zoonoses” at Nagpur Veterinary College, Maharashtra Animal and Fishery Sciences University, Nagpur with its establishment at Department of Veterinary Public Health of the institute . With a total budget outlay for Rs. 437.848 lakh granted by the ICAR, the centre conduct ed its work in collaboration with its medical partners Central India Institute of Medical Sciences (CIIMS) , Nagpur and Mahatma Gandhi Institute of Medical Sciences (MGIMS), Sewagram who recieved parallel funds by the ICMR, New Delhi. With the goal “One health concept- A targeted, multi-disciplinary and multi-sectoral efforts to mitigate the effects of zoonoses on human and animal health”. Objectives: ● To strengthen surveillance on prevalence of zoonoses. ● To provide a roadmap for improving the understanding about the ecology of zoonotic infec tions / pathogens through application of advanced approaches in molecular surveillance, pathobiology, genomics, and metagenomics. ● To estimate the magnitude of reverse zoonoses. ● To study pathogen–host–environment dynamics, and pathogen evolution To develop analytical system based on sub-typing, finger printing, sequencing and proteom ics to evaluate epidemiological and evolutionary dynamics of the zonotic pathogens ● Capacity building of the scientists, researchers, health professionals, wild life experts, envi ronmental scientists and academicians. ● To promote “One-Health” approach that links human, animal and wildlife health for pre vention and control of zoonotic infections and its drivers through holistic and interdiscipli nary approacheEnglishReports