Ranganathan, V.Malik, Jitendra KumarBabu, Naraharisetti SureshAggarwa, ManojRao, G.S.Sankar, P.TANUVAS2017-09-042017-09-042016-042278-3687http://krishikosh.egranth.ac.in/handle/1/5810030329The effect of concurrent repeated exposure of lower concentrations of lead and endosulfan were evaluated on hepatic drug metabolizing enzymes in male rats. Alterations were evaluated through changes in the phase I enzymes (viz. cytochrome P450 and cytochrome b5, aminopyrine N – demethylase and aniline p- hydroxylase) activity and phase II enzymes (viz. microsomal and cytosolic glutathione-S-transferase UDP-glucuronosyl transferase) activity in liver. Lead, when given alone at the dose of 100 ppm in drinking water and endosufan, when given alone at the dose of 10 ppm in feed, and given in combination did not change the activities of cytochrome b5, aminopyrine N – demethylase and aniline phydroxylase. When given in lower dose combination, they significantly inhibited levels of cytochrome 450, microsomal, cytosolic glutathione-S transferase and microsomal protein as compared to control and their single compounds when given alone. This study suggested that activities of xenobiotic drug metabolizing enzymes by repeated exposure to lead and endosulfan at the concentrations used in the study were not modified to produce significant toxicity in case of combined exposure.en-USVeterinary ScienceArticle