RAGHUNATH, M (MAJOR)SREENU, MAKKENARAJU, N.K.B.NAGABHUSHAN, K2020-09-192020-09-192019-12https://krishikosh.egranth.ac.in/handle/1/5810151613THESESThe present study was conducted on 24 clinical cases of geriatric male dogs presented with symptoms related to prostatic affections to the Department of Veterinary Surgery and Radiology, NTR College of Veterinary Science. The overall incidence of prostatic enlargement was observed as 78.28% cases with more incidence in smaller breeds of dogs (58.33%). Signalment and history was collected, physiological parameters and hematobiochemical parameters were evaluated, digital rectal examination, imaging procedures, USG-FNAC, urinalysis and estimation of biomarkers were done at the time of presentation and after observatory period in all dogs. Based on treatment provided all the dogs were divided into two groups as group I (n=10) provided with medical therapy, Group II (n=14) dogs, in which castration was opted as treatment of choice were included. All the haematological parameters in most of the dogs were normal. Radiological and ultrasonographic measurements revealed that prostate gland was many times enlarged at the time of presentation in dogs of both the groups. Highly elevated BUN, creatinine and ALP along with biomarkers like canine DHT and CPSE were recorded in all the dogs of both the groups. Group I dogs were treated with finasteride @ 0.5 to 1mg/kg/day for a period of 45 days. In group II dogs under general anaesthesia, open open method of castration was done under standard operating procedures. After the follow up period of 45 days all the dogs recovered from the clinical symptoms. All the radiological, ultrasonographic measurements, haematobiochemical and urinary parameters were within the normal range. Values of Prostate specific serum biomarkers also showed significant decrease in both the groups after the follow up period. Even though medical treatment with finasteride and surgical procedure of castration were effective in reducing the symptoms of prostatic hyperplasia, castration was the most effective with no signs of recurrence.EnglishThesis