LAKSHMI RANI .N (MAJOR)SURESH .KSRINIVAS .MANURADHA RAVINDRA GANGAVATI2024-07-052024-07-052023-04https://krishikosh.egranth.ac.in/handle/1/5810211491The present study was undertaken to study the renal dysfunction in dogs affected with pyometra. The occurrence of pyometra was observed to be 2.02 per cent among a total of 1383 female dogs presented during the study period. The pyometra dogs were subjected to detailed clinical and haemato-biochemical examination to assess renal function in dogs. In the present study, based on elevated levels of serum creatinine and BUN values, the pyometra dogs were categorized as azotemic (Group I) and non azotemic (Group II). The occurrence of azotemia (Group I) in dogs accounted up to 42.86 per cent whereas 57.14 per cent were non-azotemic (Group II). The occurrence of pyometra with or without azotemia was more in Pomeranian breed with majority of the dogs in the age group of 5-10 years. Clinical examination was performed to assess SIRS in pyometra dogs and revealed 36.84 per cent (Group I) and 63.16 per cent (Group II) of pyometra affected dogs were SIRS positive. Haematological examination revealed decreased haemoglobin, total erythrocyte count, lymphocyte count along with leucocytosis. DLC revealed neutrophilia with shift to left. Biochemical examination revealed elevated mean serum creatinine (mg/dL), BUN (mg/dL) and CRP (mg/L), hypoalbuminemia and hypochloremia in pyometra dogs with and without azotemia when compared to healthy control while hyponatremia was observed in azotemic bitches. Urinalysis revealed decreased specific gravity and elevation of UPCR, which showed significant difference (P<0.01) between the two groups. The prominent nephrosonographic features observed in azotemic dogs were irregular contour, indistinct cortico-medullary junction, increased/decreased cortical echogenecity and nephrocalcinosis. Doppler ultrasonography was performed to assess haemodynamic changes in kidneys revealed that the mean resistive index (RI) and the mean pulsatility index (PI) were significantly (P<0.01) elevated in pyometra dogs than healthy control. Pearson’s correlation did not demonstrate significant correlation between serum creatinine with RI and PI (P>0.05) in the present study. Significant reduction in the mean±SE of serum creatinine (P<0.01) and mean±SE of serum BUN (P<0.05) following ovario-hysterectomy as compared to pre-operative values suggested that renal dysfunction was transient in most of the pyometra dogs.EnglishThesis