VENKATGIRISHIVASHARANAPPA UKKALI2023-12-212023-12-212022https://krishikosh.egranth.ac.in/handle/1/5810204071The study was carried out to evaluate the feasibility of anaesthetic agents using guaifenesin administered tiletamine-zolazepam and ketamine-midazolam under isoflurane anaesthesia for various surgeries in cattle. The present study was conducted in 12 clinical cases of cattle presented to the Department of Veterinary Surgery and Radiology, Veterinary College, Bidar for the treatment of various surgical affections. The cattle were randomly divided into two groups consisting of six cattle in each group. The cattle of group-I were operated under guaifenesin-tiletamine-zolazepam. Guaifenesin was administered at the dose rate of 50 mg/kg body weight intravenously at 5% solution in normal saline in the form of drip. After 5 minutes, anaesthesia was induced using tiletamine-zolazepam bolus given at the dose rate of 3 mg/kg body weight intravenous and maintained with isoflurane (1-2%). The cattle of group-II were operated under guaifenesinketamine- midazolam. Guaifenesin was administered at the dose rate of 50 mg/kg body weight intravenous at 5% solution in normal saline. After 5 minutes, anaesthesia was induced by administration of ketamine at the dose rate of 3 mg/kg body weight and midazolam at the dose rate of 0.30 mg/kg body weight intravenous bolus and maintained with isoflurane (1-2%). Induction time was significantly earlier in group-I animals. The recovery time, recovery time to assume sternal recumbency, recovery time to standing position was significantly quicker in group-II animals. The degree of analgesia and muscle relaxation was significantly greater in both the group of cattle. Physiological parameters like heart rate, respiratory rate and rectal temperature decreased significantly in both the group of cattle, however they were within the normal physiological limits. Haematological parameters and biochemical parameters though changed significantly during depth of general anaesthesia in both the groups was only transient, however they were within the physiological limits. The present study concluded that, both the anaesthetic combinations (group-I and group-II) are excellent to use for orthopaedic surgeries in cattle.Thesis