Usha, SMohanty, TKSenthilkumar, PTANUVAS2019-02-192019-02-192018-12http://krishikosh.egranth.ac.in/handle/1/5810095870TNV_Ijcmas_2018_7(12)1122-1132The present study was conducted to elucidate the plasma mineral profile and serum biochemical parameters in Holstein Friesian cross bred cattle in different physiological stages and seasons. In each season and each physiological group 8 normal healthy animals randomly selected for blood sampling once in a month for minerals Ca, P, Cu, Zn and Mn; biochemical parameters glucose, BUN, and NEFA analysis. Blood plasma minerals and biochemical parameters were significantly (P<0.05) influenced by animal physiological conditions and season of the year. Whereas, season of the year did not influences the serum cholesterol level. Blood Plasma minerals estimated were within the normal range. However, mineral concentration were significantly (P<0.05) lower during winter. Similarly, glucose content was lower and the BUN and NEFA content were higher during winter compared to other season. Results indicate that the herd health status on metabolic and mineral profiles need to be evaluated regularly in different seasons to diagnose deficiencies and imbalances to achieve set targets in terms of production performance by adjusting feeding and mineral supplementation.enVeterinary ScienceArticle