Meshram, M. D.Tandale Siddeshwar Ramrao2024-02-022024-02-022023-04-03https://krishikosh.egranth.ac.in/handle/1/5810206683Contagious Ecthyma is an extremely infectious disease that affects young goats and it has high morbidity but less mortality. The goal of the current study, held under the heading "Therapeutic Management of Contagious Ecthyma in Goat" was to identify and treat contagious ecthyma in goats. There were fifty goats in total that exhibited clinical symptoms like scab lesions around their muzzles, lips, and nostrils as well as elevated body temperatures, anorexia, weakness and dehydration. Sample collection was done from the Beed, Satara, and Parbhani regions. Scab blood and serum specimens were collected. The overall prevalence was 36%. In the area-wise study, the highest prevalence was showed in Beed (Savleshwar) i.e., 62.5%. Out of total 50 animals, 18 were positive by PCR. The highest observed prevalence was 44.44% for kids under 4 months and 39.28% for bucks. The highest prevalence was recorded in the rainy season (78.3%). DNA extracted from 50 clinically ill animals and 18 out of those samples produced a 592bp amplicon. The results of a hematological analysis showed an increase in TLC and DLC except for lymphocytes (lymphocytopenia), while a significant decrease was observed in the TEC and hemoglobin. Biochemical analysis showed hypoproteinemia. Three groups of each of the six goats were treated with Amoxicillin, Aciclovir @ 5 mg/kg body weight plus Amoxicillin @ 5mg/kg body weight and Aciclovir at 10 mg/kg plus Amoxicillin respectively. The mortality rates for all three groups were zero; while the recovery rates in groups I, II, and III were 66.66%, 100%, and 100% respectively. As a result, it is suggested that Aciclovir at a dose rate of 10 mg/kg with Amoxicillin (@ 5mg/kg body weight) better than the other. In goats, Aciclovir was most effective in the treatment of contagious ecthyma..EnglishThesis