Savaliya, F. P.PANCHAL, JAYESHKUMAR RAMESHCHANDRA2018-06-112018-06-112009http://krishikosh.egranth.ac.in/handle/1/5810050623The present study was carried out to compare the levels of expression of IGF-I, IGF-II and TGF-β3 gene in liver of 24 Synthetic White Leghorn chicken from four groups (six bird/group) with different level of feed consumption and egg production and to estimate correlation between levels of gene expression on various economic traits by quantitative real time PCR using GAPDH as endogenous control. The relative expression ratio (fold of induction) for groups was determined in relation to a calibrator which was represented by the smallest signal detectable for that specific gene. There were significant (p < 0.05) differences in IGF-I expression level in four groups. Maximum level of expression was in HL group (13.81 ±3.84a) followed by, LL (13.70 ± 6.07a), LH (4.74 ± 0.91ab), and HH (2.88 ± 0.47b HL and LL groups have significantly (p<0.05) higher expression over the HH and LH. However, there were no significant differences in expression between HL and LL and between HH and LH. There were no significant differences in expression level of IGF-II and TGF-β3 in four groups. The correlation of IGF-I with Age at Sexual maturity, body weight at all ages were non significant. The correlation of IGF-1 with egg weight at 32 weeks of age was positive, high and significant (p < 0.05), whereas, with egg weight at 40, 56, 64 and 72 weeks of age were non significant. The correlations of IGF-I with egg production were negative, high and significant (p < 0.05), except with egg production up to 40 weeks of age which was non significant. The correlation between IGF-I and Total Feed consumption during 51-60 weeks of age was non significant. The correlation of IGF-II with Age at Sexual maturity, body weight at 16, 20, 32, 40, 56, 64 and 72 weeks of age were non significant. The correlation between IGF-lI and egg weight at 32, 40, 56, 64 and 72 weeks of age were non significant. The correlation of IGF-II with egg production up to 72 weeks of age was negative, high and significant (p < 0.05), while, the correlation at other ages were non significant. The correlation between IGF-II and Total Feed consumption during 51-60 weeks of age was non significant. The correlation of TGF-β3 with Age at Sexual maturity, body weight at all ages, feed consumption during 51-60 weeks and egg production at all ages were non significant. The correlation between TGF-β3 and egg weight were non significant. Feed consumption per egg (g/egg) was positive, high and significant (p<0.05) with IGF-I, while non significant with IGF-II and TGF-β3. Present finding suggests that correlation of IGF-I gene with egg production were Significant and negative while, positive with body weight at different ages and increase as age advances.enA STUDYThesis