Devanand, C BLaiju, M PhilipKAU2019-06-072019-06-072005172386http://krishikosh.egranth.ac.in/handle/1/5810107577PGThe study was conducted in twelve clinically healthy nondescript bitches presented to the clinics of College of Veterinary and Animal Sciences, Mannuthy for panhysterectomy, to evaluate the effect of preoperative dextrose infusion in alleviating stress, to promote healing and postoperative recovery. The animals were divided into two groups. In Group I, panhysterectomy was done under general anaesthesia after overnight fasting and in group II, panhysterectomy was done under general anaesthesia after overnight fasting and administration of 12.5 per cent dextrose at the rate of 5 ml per kg intravenously two hours prior to induction of anaesthesia. Physiological, haematological and biochemical parameters were estimated before surgery, immediately after surgery, at 24th hour, on 4th day and 8th day postoperatively. Cortisol concentration was estimated before surgery, immediately after surgery and at 24th hour postoperatively in Group I, and before dextrose infusion, before surgery, immediately after surgery and at 24th hour postoperatively in Group II. Wound healing and recovery were assessed during postoperative period. The duration of recovery was reduced to half in group II compared to group I. Significant difference in physiological parameters like rectal temperature, pulse rate and respiration rate could be observed among groups during the observation periods, but was not significant (P<0.05) between groups. Generalised leucopenia detected immediately after surgery and became mild leucocytosis with concurrent neutrophilia and lymphopenia were noted among groups by 24th hour postoperatively. The variation in haematological parameters was not significant between groups. There was significant (P<0.05) increase in the cortisol and glucose concentrations immediately after surgery compared to preoperative value in both the groups, but a significant (P<0.05) decrease in those animals received preoperative dextrose infusion compared to group I. The general healing pattern related to cellular and fibrous components were similar between the groups. Faster recovery and early return to normal activity and feeding habits were observed in animals received dextrose infusion in the preoperative period. In the present study preoperative dextrose infusion initiated positive benefits in terms of patient well being and postoperative outcome in dogs after panhysterectomy. The favourable outcome of the study recommends preoperative dextrose infusion in dogs for elective surgery as a protocol in future practices in animal surgery.ennullThesis