SURESH .K (MAJOR)LAKSHMI RANI .NHARI KRISHNA .N.V.VBHAVYA UDUM2024-07-052024-07-052023-05https://krishikosh.egranth.ac.in/handle/1/5810211513The present study was undertaken to record the occurrence, clinical signs, haemato-biochemical, radiographic and ultrasonographic findings as well as to undertake the therapeutic management in ascitic dogs with hepatic involvement. The occurrence of ascites with hepatic involvement among 2356 dogs presented to the small animal medicine ward recorded was 1.02 per cent. Highest occurrence of ascites with hepatic involvement was recorded in Labrador retriever breed, 1-4 years age group and in male dogs. The clinical signs observed in dogs with ascites due to hepatic involvement were abdominal distension, inappetence to anorexia, dullness to depression, dyspnoea, pale mucous membranes, fever, weight loss, vomiting, icterus, melena , limb oedema, diarrhoea , polyuria/polydipsia and petechiae. Diagnosis of ascites with hepatic involvement was done based on clinical signs, haematology, serum biochemistry, ascitic fluid analysis, radiographic and ultrasonographic findings. Haematological examination revealed anaemia with neutrophilic leucocytosis and increased prothrombin time. Mean serum biochemical findings showed elevated ALT, ALP, GGT, total bilirubin and globulin; non- significant increase in creatinine while the mean values decreased significantly with respect to total protein, albumin, A:G ratio, BUN and glucose. Ascitic fluid analysis revealed transudate predominantly with decrease in total protein and albumin concentration while the SAAG value was >1.1 g/dL. Radiographic examination of ascitic dogs revealed ground glass appearance with loss of serosal details. Ultrasonographic examination revealed anechoic free fluid along with hyper/hypoechoic liver which was normal, enlarged or shrunken; focal fatty infiltration and gall bladder disorders. Therapeutic management was carried out in 18 dogs with ascites due to hepatic involvement by dividing them into 2 groups using two therapeutic regimens. In ascitic dogs with hepatic involvement therapeutic management was done with ursodeoxycholic acid (UDCA) and silybin phosphatidyl choline complex in Group I while Group II dogs were treated with silybin phosphatidyl choline complex alone. Dogs of both the groups were treated with antibiotic, diuretic and supportive therapy. Both the regimens were efficacious in the management of ascites with hepatic involvement while the Group I dogs treated with UDCA and silybin phosphatidyl choline complex showed faster clinical recovery.EnglishThesis