Prajapati, K. S.GHODASARA, PRIYA D.2018-06-112018-06-112014http://krishikosh.egranth.ac.in/handle/1/5810051016The present research work was conducted on eight groups of day old Cobb-400 broiler chicks to study the toxicopathological effects of meloxicam, ibuprofen and diclofenac sodium in feed. Group I was kept as control. Group II was administered with diclofenac at dose of 15 ppm through feed. Groups III, IV and V were fed with diet containing meloxicam @ 4, 20 and 100 ppm respectively for 21 days. Groups VI, VII and VIII were fed with diet containing ibuprofen @ 80 ppm, 400 ppm and 2000 ppm respectively for 21 days. The chicks were observed for any abnormal behavioral signs and mortality during the experiment. After completion of 21 days treatment, blood samples were collected for serum biochemical analysis from right jugular vein. The survived birds were sacrificed by means of cervical dislocation at the end of experiment. A detailed post mortem examination was performed on chicks which died during the experiment as well as sacrificed at the end of the experiment and gross lesions were recorded. Tissue samples (liver, kidney, heart, spleen and lung) were collected in 10% formalin for histopathological examination. Clinical signs viz. dullness, depression, anorexia, lameness, unthriftiness with ruffled feather, drooping of the wings and lethargy with shrunken eyes were noticed in birds of diclofenac treated group II. During the study the mortality was observed in diclofenac treated group II and it was 25%. Meloxicam and ibuprofen treated birds did not reveal any mortality. Reduction in body weight gain and feed intake and increase in Kidney : Bodyweight ratio were observed in diclofenac treated group II as compare to control group. Meloxicam and ibuprofen treated groups did not reveal any significant change in body weight gain, feed intake and Kidney : Body weight ratio as compare to control group. The average FCR was higher in diclofenac treated group II (3.82) as compared to control group (2.19). Meloxicam and ibuprofen treated groups did not reveal any changes in this parameter as compared to control. There was highly significant rise (p < 0.01) in mean values of uric acid and BUN whereas significant increase in creatinine, AST and ALT in diclofenac treated group II. Ibuprofen treated group- VIII with high dose revealed significant increase in AST and ALT. Meloxicam treated groups did not reveal any changes in these biochemical parameters as compare to control. Pathological lesions (both gross and microscopic) were mainly observed in chicks that died during the experiment from diclofenac treated group II. The chicks which were sacrificed at the end of experiment did not reveal any specific gross and microscopic lesions in any of the treatment group. Grossly, on surface of visceral organs white chalky urate deposits of varying degree were observed in chicks which died during experiment from treatment group II. Histopathologically, the lesions were characterized by congestion, degeneration, haemorrhage and deposition of uric acid crystals. Kidney was the main target organ affected. The overall lesions gave an impression that diclofenac was nephrotoxic as well as hepatotoxic in nature. Ibuprofen treated group VIII with high dose showed slightly enlarged and pale liver in few birds while meloxicam treated groups did not reveal any pathomorphological changes.enVETERINARY PATHOLOGYA STUDYThesis