Changkija, BendanglaNakang, Habung2019-08-032019-08-032017-07http://krishikosh.egranth.ac.in/handle/1/5810118884The present study entitled “Haemato-biochemical alterations in canine renal dysfunction and it’s therapeutic management” was undertaken w.e.f. 1st August 2016 to 31st May 2017 with the objective to study the prevalence, clinical signs and haematobiochemical alterations in dogs with renal dysfunction and to assess the efficacy of the therapy adopted in stage III and IV of renal dysfunction in dogs. The study revealed overall prevalence of 25.88% of renal dysfunction with higher occurrence in Labrador breed (38.64%) with male predominance (68.18%) and in age group of 6-10 years (72.73%). Clinical signs associated with renal dysfunction were anorexia weight loss weakness vomiting, emaciation, pale mucous membrane, polyuria, polydipsia inappetance, recumbency, anuria, halitosis, oral ulcers, epistaxis, seizure, congested mucous membrane and cataract/blindness. Haematology revealed anemia and severe protienuria with highly significant elevation in BUN, serum creatinine and phosphorous in dogs with renal dysfunction when compared with apparently healthy control dogs. A non-significant elevation of serum sodium and potassium and fall in total protein and albumin levels were also observed in dogs with renal dysfunction. Combination of rubenal and conservative treatment using supportive drugs, was found to be more effective in the therapeutic management of renal dysfunction in stages III and IV with a survivality rate of 90% when compared to prednisolone with supportive drugs and a combine therapy using both prednisolone and rubenal along with supportive drugs.ennullThesis