Manikandan, R.Dharmaceelan, S.Jayakumar, K.Senthilkumar, S.Selvaraj, P.TANUVAS2019-06-042019-06-042019-05http://krishikosh.egranth.ac.in/handle/1/5810106755TNV_IVJ_May2019_96(05)_34-37A clinical study was conducted in 24 dogs to compare the cardiopulmonary and isoflurane sparing effects on inclusion of meloxicam, ketoprofen, tolfenamic acid and flunixin in general anaesthetic protocol of dogs. Meloxicam, ketoprofen, tolfenamic acid and flunixin were administered @ 0.2, 2.0, 4.0 and 1.0 mg per kg i.v.in group I, II, III and IV animals, respectively. Midazolam was administered @ 0.3 mg per kg i.v. to all the animals. General anaesthesia was induced with propofol @ 6 mg/kg i.v. in all the animals and maintained with isoflurane. Ovariohysterectomy (OHE) was performed as per the standard technique. The tidal volume (VT), minute volume (VE), saturation of peripheral oxygen (SpO2), mean arterial pressure (MAP) and electrocardiography (ECG) were recorded. Fraction of inspired-oxygen, end-tidal oxygen, fraction of inspired-carbon dioxide, end-tidal carbon dioxide, fraction of inspired-isoflurane and end-tidal isoflurane concentration were also recorded continuously during maintenance of anaesthesia. The postoperative analgesic efficacy of meloxicam and ketoprofen was found superior than tolfenamic acid and flunixin. No major alterations in cardiopulmonary functions were noticed by the inclusion of NSAIDs in the anaesthetic protocol of dogs. Meloxicam had a significant isoflurane sparing effect than other drugs.en-USVeterinary ScienceVeterinary Surgery and RadiologyArticle