Dr. Santosh P. SarangamathSACHINKUMAR2024-09-132024-09-132024https://krishikosh.egranth.ac.in/handle/1/5810214477The present study was conducted to record the occurrence of hepatic insufficiency in dogs in and around Bidar, to study the clinical and haematobichemical changes, diagnostic efficacy of hepatic markers and therapeutic efficacy in hepatic insufficiency. During present study a total 1220 cases were presented to veterinary clinical complex, veterinary college bidar from July 2023 to Februarys 2024. Out of 1220 cases 23 dogs were diagnosed with hepatic insufficiency which represents a prevalence of 1.88%. It was found that dogs belonging to the age group of 2-6 years (53.17%) were affected more in number and Golden Retriever had higher occurrence followed by Labrador retriever. Male (60.86%) dogs had higher occurrence of hepatic insufficiency than female (39.13%) dogs. Inappatence, weakness, dullness and weight loss were the most predominant clinical signs followed by ascites and pyrexia. Concurrent infection with Ehrlichiosis and Babesiosis among hepatic insufficiency dogs was 4.34% and 8.68% respectively. Haematological examination revealed decrease in haemoglobin, erythrocytes, PCV, lymphocytes and platelets, along with increase in total leucocytes and neutrophils. Biochemical parameters revealed increase in ALT, AST, ALP. And prothrombin time and decrease in albumin and A/G ratio. Use of S – adenosyl methionine + silybin was more effective in treatment for hepatic insufficiency in dogs compared to administration of Ursodeoxycholic acid and syrup Liv-52 based on early and higher recovery rate.EnglishThesis