Evaluation of profenofos induced oxidative stress and genotoxicity in female albino rat
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Date
2016
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Punjab Agricultural University, Ludhiana
Abstract
The present study was conducted to investigate the toxic effects of profenofos on female
albino rats at two subchronic doses of 1/10th and 1/50th of LD50 (430.89 mg/kg b.w.) for six
weeks. Commercial formulation of profenofos (Curacron 50 EC) was used for treatment.
Hyperactivity was observed in rats treated with 1/10th of LD50 of profenofos. Relative weight
of reproductive organs was found to be significantly decreased in treated rats. Feed intake and
estrous cyclicity was found to be significant during treatment. Biochemical parameters like
total proteins, lipids, phospholipids, cholesterol and phosphatases decreased significantly in
ovaries of treated rats as compared to the control rats. Antioxidant activity, concentration of
antioxidative enzymes and lipid peroxidation showed alterations in treated rats. Microsomal
degranulation increased at dose dependent manner which indicated that profenofos has a
potential for carcinogenicity. Increase in the frequencies of micronucleated polychromatic
erythrocytes emphasised the genotoxic effect of profenofos in bone marrow cells of treated
rats. Levels of estrogen and luteinising hormone increased while progesterone and follicle
stimulating hormone decreased significantly in plasma of treated rats. Follicular atresia also
increased in ovaries of treated rats. Histological examination of female reproductive organs in
treated rats also showed significant alterations. Profenofos intoxication through hormones has
resulted in biochemical and histopathological changes in reproductive parameters in treated
female rats.
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